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Explain briefly the significance

Task Write a short report (~1000 words) on the function of the prion protein gene (PRNP). In this report please detail: Explain briefly the significance of the prion protein gene (PRNP) protein in health. Its chromosomal location. How long is the gene? Does the gene have any introns? How long is the protein? How many variants have been described? Given that prion protein gene (PRNP) originated in early mammalian ancestors – test the hypothesis that the prion protein gene (PRNP) proteins in any 3 mammalian species are similar, by making an alignment of the 3 protein sequences in UniProt. The amino acid at position 129 is associated with susceptibility to vCJD. Make a model of the human prion protein using Swiss-Model and note where the polymorphic 129 position is. Looking at the population genetic studies summarised in ENSEMBL, which population would likely be the least susceptible to vCJD? Guidance Make use of figures and accompanying legends the appropriateness of these figures will contribute to your mark. Remember to reference correctly in the Harvard style. Use appropriate scientific English.

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